News

Updates

ALL PUBLICATION TECH MINI-OCTAL OCTAL
Apr 2026 MINI-OCTAL

Mini-OCTAL now supports 44 languages. The April 2026 expansion adds Swedish, Danish, Finnish, Hungarian, Czech, Russian, Bulgarian, Greek, Japanese, Korean, Indonesian, Vietnamese, Hindi, Amharic, Brazilian Portuguese, and an Africa-focused batch (Shona, Northern Ndebele, Zulu, Afrikaans, Kiswahili, Hausa) — supporting deployments across Europe, East and Southeast Asia, South Asia, the Americas, and across Africa. All languages have been or will be proofread by native speaker(s) before testing locally. We really hope we can contribute to global neuroscience!

Apr 2026 TECH MINI-OCTAL

Researchers and clinicians can now track participant progress in real time. A live web dashboard is available for every Mini-OCTAL project, showing at a glance which participants have completed which tasks — no technical knowledge required. Green means done, grey means outstanding. The dashboard updates automatically within minutes of a participant finishing, so study teams always have an up-to-date picture of data collection without needing to contact the research team.

Apr 2026 TECH MINI-OCTAL

Our analysis pipeline has been migrated from MATLAB/Windows to Python running on AWS Linux, reducing costs and significantly improving efficiency. AWS runs 24/7, meaning participant data is processed automatically the moment it arrives — day or night. Preprocessed results for each task are saved directly to each project’s repository, ready for download.

Apr 2026 TECH MINI-OCTAL

Participant ID field locks automatically when pre-filled via URL, preventing accidental edits in longitudinal studies.

Mar 2026 MINI-OCTAL

Spanish translation proofread by native speaker (visiting student Miss Ines Millan Martin).

Jan 2026 PUBLICATION OCTAL

OCTAL methods paper published in npj Digital Medicine — 1,664 participants, AUC 0.96. [Zhao et al. 2026]

Nov 2025 PUBLICATION OCTAL

Preprint: OCTAL + NULISA proteomics in 391 patients identifies cognitive resilience biomarkers. [Toniolo, Zhao et al. 2025]

Jan 2025 MINI-OCTAL

MiniOCTAL now supports 23 languages including Arabic, Farsi, Bengali, Tamil, and Traditional Chinese.

Apr 2024 PUBLICATION OCTAL

OCTAL identifies Alzheimer’s remotely; performance correlates with plasma pTau181. [Toniolo, Zhao et al. 2024]

Feb 2024 PUBLICATION OCTAL

Long-COVID patients show severe cognitive slowing on SRT; non-long-COVID had normal speed. [Zhao et al. 2024]

Jan 2022 PUBLICATION OCTAL

Number Vigilance Task detects attention decline in 2 min; COVID-19 patients showed minor deficit. [Zhao et al. 2022]

Publications

* denotes co-first authors

Toniolo, S., Zhao, S. et al. (2025). Novel markers of cognitive impairment and resilience using digital and plasma biomarkers across different neurodegenerative diseases. medRxiv (preprint).
Alzheimer’s disease Plasma biomarker

Zhao, S.*, Toniolo, S.* et al. (2026). Remote digital cognitive assessment for aging and dementia using the Oxford Cognitive Testing Portal OCTAL. npj Digital Medicine.
⭐This is OCTAL’s key methods paper⭐
Alzheimer’s disease Ageing

Toniolo, S.*, Zhao, S.* et al. (2024). Relationship of plasma biomarkers to digital cognitive tests in Alzheimer’s disease. Alzheimer’s & Dementia: DADM.
Alzheimer’s disease Plasma biomarker

Zhao, S. et al. (2024). Cognitive slowing in long-COVID revealed by a simple reaction time measure. eClinicalMedicine.
Long COVID

Zhao, S. et al. (2022). Rapid vigilance and episodic memory decrements in COVID-19 survivors. Brain Communications.
Long COVID